Relevant factors for neurologists to define effectiveness of migraine preventive drugs and take decisions on treatment. My- LIFE European Delphi survey

European Journal of Pain 2021 Nov;25(10):2177-2189 doi: 10.1002/ejp.1831. Epub 2021 Jul 13. Patricia Pozo-Rosich, Raquel Gil-Gouveia, Anne Donnet, Anne-Christine Poole, Astrid Gendolla, Shazia Afridi, Rainel Sanchez-De la Rosa, Gisela M Terwindt, Cristina Tassorelli Abstract Background: Clinical guidelines agree that preventive treatment should be considered in patients with uncontrolled

Initiation of migraine-related cortical spreading depolarization by hyperactivity of GABAergic neurons and NaV1.1 channels

The Journal of clinical investigation 2021 Nov 01;131(21):e142203. doi: 10.1172/JCI142203. Oana Chever, Sarah Zerimech, Paolo Scalmani, Louisiane Lemaire, Lara Pizzamiglio, Alexandre Loucif, Marion Ayrault, Martin Krupa, Mathieu Desroches, Fabrice Duprat, Isabelle Léna, Sandrine Cestèle, Massimo Mantegazza Abstract Spreading depolarizations (SDs) are involved in migraine, epilepsy, stroke, traumatic brain injury, and subarachnoid hemorrhage.

Episodic syndromes that may be associated with migraine: What adult neurologists need to know

Revue Neurologique 2021 Sep;177(7):773-778.doi: 10.1016/j.neurol.2021.07.002. Epub 2021 Aug 5. S Redon Abstract Four episodic syndromes are recognized in the current version of the International Classification of Headache Disorders (ICHD): cyclic vomiting syndrome (CVS); abdominal migraine; benign paroxysmal vertigo; benign paroxysmal

Revised guidelines of the French headache society for the diagnosis and management of migraine in adults. Part 3: Non-pharmacological treatment

Revue Neurologique 2021 Sep;177(7):753-759 G Demarquay, J Mawet, E Guégan-Massardier, S de Gaalon, A Donnet, P Giraud, M Lantéri-Minet, C Lucas, X Moisset, C Roos, D Valade, A Ducros Abstract The French Headache Society proposes updated French guidelines for the

Revised guidelines of the French headache society for the diagnosis and management of migraine in adults. Part 2: Pharmacological treatment

Revue Neurologique 2021 Sep;177(7):734-752. A Ducros, S de Gaalon, C Roos, A Donnet, P Giraud, E Guégan-Massardier, M Lantéri-Minet, C Lucas, J Mawet, X Moisset, D Valade, G Demarquay Abstract The French Headache Society proposes updated French guidelines for the

Revised guidelines of the French Headache Society for the diagnosis and management of migraine in adults. Part 1: Diagnosis and assessment

Revue Neurologique 2021 Sep;177(7):725-733. G Demarquay, X Moisset, M Lantéri-Minet, S de Gaalon, A Donnet , P Giraud, E Guégan-Massardier, C Lucas, J Mawet, C Roos, D Valade, A Ducro Abstract The French Headache Society proposes updated French guidelines for

TREK channel activation suppresses migraine pain phenotype

iScience 2021 Aug 8;24(9):102961 doi: 10.1016/j.isci.2021.102961. eCollection 2021 Sep 24. Pablo Ávalos Prado , Arnaud Landra-Willm , Clément Verkest  , Aurore Ribera  , Anne-Amandine Chassot  , Anne Baron  , Guillaume Sandoz. Abstract Activation and sensitization of trigeminal ganglia (TG) sensory neurons, leading to the release of

Modeling NaV1.1/SCN1A sodium channel mutations in a microcircuit with realistic ion concentration dynamics suggests differential GABAergic mechanisms leading to hyperexcitability in epilepsy and hemiplegic migraine

PLoS computational biology 2021 Jul 27;17(7):e1009239. doi: 10.1371/journal.pcbi.1009239. eCollection 2021 Jul. Louisiane Lemaire, Mathieu Desroches, Martin Krupa, Lara Pizzamiglio, Paolo Scalmani , Massimo Mantegazza Abstract Loss of function mutations of SCN1A, the gene coding for the voltage-gated sodium channel NaV1.1, cause different types of epilepsy,