Nature Reviews Neurology 18 June 2021 https://doi.org/10.1038/s41582-021-00509-5 Anna K. Eigenbrodt, Håkan Ashina, Sabrina Khan, Hans-Christoph Diener, Dimos D. Mitsikostas, Alexandra J. Sinclair, Patricia Pozo-Rosich, Paolo Martelletti, Anne Ducros, Michel Lantéri-Minet, Mark Braschinsky, Margarita Sanchez del Rio, Oved Daniel, Aynur Özge,