Relevant factors for neurologists to define effectiveness of migraine preventive drugs and take decisions on treatment. My- LIFE European Delphi survey

European Journal of Pain 2021 Nov;25(10):2177-2189 doi: 10.1002/ejp.1831. Epub 2021 Jul 13. Patricia Pozo-Rosich, Raquel Gil-Gouveia, Anne Donnet, Anne-Christine Poole, Astrid Gendolla, Shazia Afridi, Rainel Sanchez-De la Rosa, Gisela M Terwindt, Cristina Tassorelli Abstract Background: Clinical guidelines agree that preventive treatment should be considered in patients with uncontrolled

Initiation of migraine-related cortical spreading depolarization by hyperactivity of GABAergic neurons and NaV1.1 channels

The Journal of clinical investigation 2021 Nov 01;131(21):e142203. doi: 10.1172/JCI142203. Oana Chever, Sarah Zerimech, Paolo Scalmani, Louisiane Lemaire, Lara Pizzamiglio, Alexandre Loucif, Marion Ayrault, Martin Krupa, Mathieu Desroches, Fabrice Duprat, Isabelle Léna, Sandrine Cestèle, Massimo Mantegazza Abstract Spreading depolarizations (SDs) are involved in migraine, epilepsy, stroke, traumatic brain injury, and subarachnoid hemorrhage.