Severe migraine and its control: A proposal for definitions and consequences for care

Revue Neurologique 2021 Mar 30; doi: 10.1016/j.neurol.2020.11.012.  Anne Donnet  , Anne Ducros  , Françoise Radat  , Bashar Allaf  , Isabelle Chouette  , Michel Lanteri-Minet Abstract Currently many patients with severe migraine do not receive appropriate treatment and are never referred to specialist headache centres.

Mambalgin-1 pain-relieving peptide locks the hinge between α4 and α5 helices to inhibit rat acid-sensing ion channel 1a

Neuropharmacology 2021 Mar 1;185:108453. doi: 10.1016/j.neuropharm.2021.108453. Epub 2021 Jan 12. Miguel Salinas, Pascal Kessler, Dominique Douguet, Daad Sarraf, Nicolo Tonali, Robert Thai, Denis Servent, Eric Lingueglia Abstract Acid-sensing ion channels (ASICs) are proton-gated cationic channels involved in pain and other processes, underscoring the potential therapeutic value of