Initiation of migraine-related cortical spreading depolarization by hyperactivity of GABAergic neurons and NaV1.1 channels

The Journal of clinical investigation 2021 Nov 01;131(21):e142203. doi: 10.1172/JCI142203. Oana Chever, Sarah Zerimech, Paolo Scalmani, Louisiane Lemaire, Lara Pizzamiglio, Alexandre Loucif, Marion Ayrault, Martin Krupa, Mathieu Desroches, Fabrice Duprat, Isabelle Léna, Sandrine Cestèle, Massimo Mantegazza Abstract Spreading depolarizations (SDs) are involved in migraine, epilepsy, stroke, traumatic brain injury, and subarachnoid hemorrhage.

Modeling NaV1.1/SCN1A sodium channel mutations in a microcircuit with realistic ion concentration dynamics suggests differential GABAergic mechanisms leading to hyperexcitability in epilepsy and hemiplegic migraine

PLoS computational biology 2021 Jul 27;17(7):e1009239. doi: 10.1371/journal.pcbi.1009239. eCollection 2021 Jul. Louisiane Lemaire, Mathieu Desroches, Martin Krupa, Lara Pizzamiglio, Paolo Scalmani , Massimo Mantegazza Abstract Loss of function mutations of SCN1A, the gene coding for the voltage-gated sodium channel NaV1.1, cause different types of epilepsy,

Fluorescent- and tagged-protoxin II peptides: potent markers of the Na v 1.7 channel pain target

British journal of pharmacology 2021 Jul;178(13):2632-2650 doi: 10.1111/bph.15453. Epub 2021 May 14. Jérôme Montnach , Stephan De Waard, Sébastien Nicolas, Sophie Burel, Nancy Osorio, Claude Zoukimian, Massimo Mantegazza, Rachid Boukaiba, Rémy Béroud, Michel Partiseti, Patrick Delmas, Céline Marionneau, Michel De Waard Abstract Background and purpose: Protoxin II (ProTx II) is a high

Gain of Function for the SCN1A/hNav1.1-L1670W Mutation Responsible for Familial Hemiplegic Migraine.

Front Mol Neurosci. 2018 Jul 9;11:232. doi: 10.3389/fnmol.2018.00232. eCollection 2018. Dhifallah S1, Lancaster E2, Merrill S2, Leroudier N1, Mantegazza M1, Cestèle S1. Author information Abstract The SCN1A gene encodes for the voltage-dependent Nav1.1 Na+ channel, an isoform mainly expressed in