Acid-sensing ion channel 3 mediates pain hypersensitivity associated with high-fat diet consumption in mice

Pain 2023 Sep 21.doi: 10.1097/j.pain.0000000000003030. Online ahead of print. Ahmed Negm, Katharina Stobbe, Selma Ben Fradj, Clara Sanchez, Arnaud Landra-Willm, Margaux Richter, Lucile Fleuriot, Delphine Debayle, Emmanuel Deval, Eric Lingueglia, Carole Rovere, Jacques Noel   Abstract Lipid-rich diet is the major cause of obesity, affecting 13% of the worldwide adult

Dual contribution of ASIC1a channels in the spinal processing of pain information by deep projection neurons revealed by computational modeling

PLoS computational biology 2023 Apr 17;19(4):e1010993.doi: 10.1371/journal.pcbi.1010993. eCollection 2023 Apr. Magda Chafaï, Ariane Delrocq, Perrine Inquimbert, Ludivine Pidoux, Kevin Delanoe, Maurizio Toft, Frederic Brau, Eric Lingueglia, Romain Veltz, Emmanuel Deval Abstract Dorsal horn of the spinal cord is an important crossroad of pain neuraxis, especially for the neuronal plasticity

Identification of Lipid Biomarkers for Chronic Joint Pain Associated with Different Joint Diseases

Biomolecules 2023 Feb 9;13(2):342. doi: 10.3390/biom13020342. Spiro Khoury, Jenny Colas, Véronique Breuil, Eva Kosek, Aisha S Ahmed, Camilla I Svensson, Fabien Marchand, Emmanuel Deval, Thierry Ferreira Abstract Lipids, especially lysophosphatidylcholine LPC16:0, have been shown to be involved in chronic joint pain through the activation of acid-sensing ion

TREK channel activation suppresses migraine pain phenotype

iScience 2021 Aug 8;24(9):102961 doi: 10.1016/j.isci.2021.102961. eCollection 2021 Sep 24. Pablo Ávalos Prado , Arnaud Landra-Willm , Clément Verkest  , Aurore Ribera  , Anne-Amandine Chassot  , Anne Baron  , Guillaume Sandoz. Abstract Activation and sensitization of trigeminal ganglia (TG) sensory neurons, leading to the release of