PAIN 2024 Feb 1;165(2):470-486. doi: 10.1097/j.pain.0000000000003030. Ahmed Negm, Katharina Stobbe, Selma Ben Fradj, Clara Sanchez, Arnaud Landra-Willm, Margaux Richter, Lucile Fleuriot, Delphine Debayle, Emmanuel Deval, Eric Lingueglia, Carole Rovere, Jacques Noel Abstract Lipid-rich diet is the major cause of obesity, affecting 13% of the worldwide adult population. Obesity is a
Dual contribution of ASIC1a channels in the spinal processing of pain information by deep projection neurons revealed by computational modeling
PLoS computational biology 2023 Apr 17;19(4):e1010993.doi: 10.1371/journal.pcbi.1010993. eCollection 2023 Apr. Magda Chafaï, Ariane Delrocq, Perrine Inquimbert, Ludivine Pidoux, Kevin Delanoe, Maurizio Toft, Frederic Brau, Eric Lingueglia, Romain Veltz, Emmanuel Deval Abstract Dorsal horn of the spinal cord is an important crossroad of pain neuraxis, especially for the neuronal plasticity
A photoswitchable inhibitor of TREK channels controls pain in wild-type intact freely moving animals
Nature communications . 2023 Mar 1;14(1):1160. doi: 10.1038/s41467-023-36806-4. Arnaud Landra-Willm, Ameya Karapurkar, Alexia Duveau, Anne Amandine Chassot, Lucille Esnault, Gerard Callejo, Marion Bied, Stephanie Häfner, Florian Lesage, Brigitte Wdziekonski, Anne Baron, Pascal Fossat, Laurent Marsollier, Xavier Gasull, Eric Boué-Grabot, Michael A Kienzler, Guillaume Sandoz Abstract By endowing light control of neuronal activity, optogenetics and photopharmacology are
Identification of Lipid Biomarkers for Chronic Joint Pain Associated with Different Joint Diseases
Biomolecules 2023 Feb 9;13(2):342. doi: 10.3390/biom13020342. Spiro Khoury, Jenny Colas, Véronique Breuil, Eva Kosek, Aisha S Ahmed, Camilla I Svensson, Fabien Marchand, Emmanuel Deval, Thierry Ferreira Abstract Lipids, especially lysophosphatidylcholine LPC16:0, have been shown to be involved in chronic joint pain through the activation of acid-sensing ion
Mechanisms of Action of the Peptide Toxins Targeting Human and Rodent Acid-Sensing Ion Channels and Relevance to Their In Vivo Analgesic Effects
Toxins 2022 Oct 17;14(10):709.doi: 10.3390/toxins14100709. Clément Verkest, Miguel Salinas, Sylvie Diochot, Emmanuel Deval, Eric Lingueglia, Anne Baron Abstract Acid-sensing ion channels (ASICs) are voltage-independent H+-gated cation channels largely expressed in the nervous system of rodents and humans. At least six isoforms (ASIC1a, 1b, 2a, 2b,
Antibody-induced pain-like behavior and bone erosion: links to subclinical inflammation, osteoclast activity, and acid-sensing ion channel 3-dependent sensitization
Pain 2022 Aug 1;163(8):1542-1559.doi: 10.1097/j.pain.0000000000002543. Epub 2021 Nov 19. Alexandra Jurczak, Lauriane Delay, Julie Barbier, Nils Simon, Emerson Krock, Katalin Sandor , Nilesh M Agalave, Resti Rudjito, Gustaf Wigerblad, Katarzyna Rogóż, Arnaud Briat, Elisabeth Miot-Noirault, Arisai Martinez-Martinez, Dieter Brömme, Caroline Grönwall, Vivianne Malmström, Lars Klareskog, Spiro Khoury, Thierry Ferreira, Bonnie Labrum, Emmanuel Deval, Juan Miguel Jiménez-Andrade, Fabien Marchand, Camilla I Svensson Erratum in
Single Subcutaneous Injection of Lysophosphatidyl-Choline Evokes ASIC3-Dependent Increases of Spinal Dorsal Horn Neuron Activity
Frontiers in molecular neuroscience 2022 Jun 14;15:880651 doi: 10.3389/fnmol.2022.880651. eCollection 2022. Ludivine Pidoux, Kevin Delanoe, Julie Barbier, Fabien Marchand, Eric Lingueglia, Emmanuel Deval Abstract Lysophosphatidyl-choline (LPC), a member of the phospholipid family, is an emerging player in pain. It is known to modulate different pain-related
Regulation of two-pore-domain potassium TREK channels and their involvement in pain perception and migraine
Neuroscience letters 2022 Mar 16;773:136494 doi: 10.1016/j.neulet.2022.136494. Epub 2022 Jan 31. Pablo Ávalos Prado, Anne-Amandine Chassot, Arnaud Landra-Willm, Guillaume Sandoz Abstract The ability to sense pain signals is closely linked to the activity of ion channels expressed in nociceptors, the first neurons that
Initiation of migraine-related cortical spreading depolarization by hyperactivity of GABAergic neurons and NaV1.1 channels
The Journal of clinical investigation 2021 Nov 01;131(21):e142203. doi: 10.1172/JCI142203. Oana Chever, Sarah Zerimech, Paolo Scalmani, Louisiane Lemaire, Lara Pizzamiglio, Alexandre Loucif, Marion Ayrault, Martin Krupa, Mathieu Desroches, Fabrice Duprat, Isabelle Léna, Sandrine Cestèle, Massimo Mantegazza Abstract Spreading depolarizations (SDs) are involved in migraine, epilepsy, stroke, traumatic brain injury, and subarachnoid hemorrhage.
C-Jun N-Terminal Kinase Post-Translational Regulation of Pain-Related Acid-Sensing Ion Channels 1b and 3
The Journal of neuroscience : the official journal of the Society for Neuroscience 2021 Oct 20;41(42):8673-8685 doi: 10.1523/JNEUROSCI.0570-21.2021. Epub 2021 Aug 11. Clément Verkest , Sylvie Diochot, Eric Lingueglia, Anne Baron Abstract Neuronal proton-gated acid-sensing ion channels (ASICs) participate in the detection of