Modeling NaV1.1/SCN1A sodium channel mutations in a microcircuit with realistic ion concentration dynamics suggests differential GABAergic mechanisms leading to hyperexcitability in epilepsy and hemiplegic migraine

PLoS computational biology 2021 Jul 27;17(7):e1009239. doi: 10.1371/journal.pcbi.1009239. eCollection 2021 Jul. Louisiane Lemaire, Mathieu Desroches, Martin Krupa, Lara Pizzamiglio, Paolo Scalmani , Massimo Mantegazza Abstract Loss of function mutations of SCN1A, the gene coding for the voltage-gated sodium channel NaV1.1, cause different types of epilepsy,

Fluorescent- and tagged-protoxin II peptides: potent markers of the Na v 1.7 channel pain target

British journal of pharmacology 2021 Jul;178(13):2632-2650 doi: 10.1111/bph.15453. Epub 2021 May 14. Jérôme Montnach , Stephan De Waard, Sébastien Nicolas, Sophie Burel, Nancy Osorio, Claude Zoukimian, Massimo Mantegazza, Rachid Boukaiba, Rémy Béroud, Michel Partiseti, Patrick Delmas, Céline Marionneau, Michel De Waard Abstract Background and purpose: Protoxin II (ProTx II) is a high

Occipital nerve stimulation for chronic cluster headache (COMMENT)

COMMENT in The Lancet Neurology July 01, 2021 | Volume 20, ISSUE 7, P498-499 https://doi.org/10.1016/S1474-4422(21)00163-0 Denys Fontaine, Michel Lantéri-Minet Cluster headache is a primary headache disorder characterised by attacks of strictly unilateral severe pain lasting 15–180 min, associated with prominent

Burden and attitude to resistant and refractory migraine: a survey from the European Headache Federation with the endorsement of the European Migraine & Headache Alliance

The Journal of Headache and Pain 2021 May 18;22(1):39. doi: 10.1186/s10194-021-01252-4. Simona Sacco, Christian Lampl, Antoinette Maassen van den Brink, Valeria Caponnetto, Mark Braschinsky, Anne Ducros, Patrick Little, Patricia Pozo-Rosich, Uwe Reuter, Elena Ruiz de la Torre, Margarita Sanchez Del

Phantom vision after eye removal: prevalence, features and related risk factors

The British Journal of Ophthalmology 2021 May 12; doi: 10.1136/bjophthalmol-2021-319091.  Arnaud Martel  , Stephanie Baillif  , Pierre Thomas  , Fabien Almairac  , Olivier Galatoire  , Mehrad Hamedani  , Denys Fontaine  , Michel Lanteri-Minet  Abstract Aim: Phantom eye syndrome is a poorly understood and underestimated complication of eye

Long-Term Efficacy and Safety of Erenumab: Results From 64 Weeks of the LIBERTY Study

Neurology 2021 Apr 28; doi: 10.1212/WNL.0000000000012029. Peter J Goadsby  , Uwe Reuter  , Michel Lanteri-Minet  , Gabriel Paiva da Silva Lima  , Peggy Hours-Zesiger  , Chrystel Fernandes  , Shihua Wen  , Nadia Tenenbaum  , Aditi Kataria  , Michel D Ferrari  , Jan Klatt  Abstract Objective: To report the efficacy and

Occipital Nerve Stimulation for Refractory Chronic Cluster Headache: A Cost-Effectiveness Study

Neuromodulation 2021 Apr22 doi: 10.1111/ner.13394.  Julie Bulsei, Aurélie Leplus, Anne Donnet, Jean Regis , Christian Lucas , Nadia Buisset, Sylvie Raoul, Evelyne Guegan-Massardier, Stéphane Derrey , Bechir Jarraya, Dominique Valade, Caroline Roos, Christelle Creach , Stéphan Chabardes , Pierric Giraud, Jimmy Voirin, Sophie Colnat-Coulbois, Francois Caire, Philippe Rigoard , Eric Fontas