Identification of Lipid Biomarkers for Chronic Joint Pain Associated with Different Joint Diseases

Biomolecules 2023 Feb 9;13(2):342. doi: 10.3390/biom13020342. Spiro Khoury, Jenny Colas, Véronique Breuil, Eva Kosek, Aisha S Ahmed, Camilla I Svensson, Fabien Marchand, Emmanuel Deval, Thierry Ferreira Abstract Lipids, especially lysophosphatidylcholine LPC16:0, have been shown to be involved in chronic joint pain through the activation of acid-sensing ion

Guidelines of the International Headache Society for Controlled Clinical Trials in Cluster Headache

Cephalalgia 2022 Dec;42(14):1450-1466 doi: 10.1177/03331024221120266. Epub 2022 Oct 21. Jean Schoenen, Agneta Henriette Snoer, Roemer B Brandt, Rolf Fronczek, Diana Y Wei, Chin-Sang Chung, Hans-Christoph Diener, David W Dodick, Denys Fontaine, Peter J Goadsby, Manjit Singh Matharu, Arne May, James S McGinley, Stewart J Tepper, Rigmor Højland Jensen, Michel D Ferrari; IHS Standing Committee for Clinical

Sympathetic skin response as an objective tool to estimate stimulus-associated arousal in a human model of hyperalgesia

Neurophysiologie clinique = Clinical neurophysiology 2022 Nov;52(6):436-445. doi: 10.1016/j.neucli.2022.10.002. Epub 2022 Oct 26. Charbel Salameh, Caroline Perchet, Koichi Hagiwara, Luis Garcia-Larrea Abstract Background: Pain is a private experience, whose assessment relies on subjective self-reporting. Inaccurate communication renders pain evaluation unreliable in individuals with alteration of

Mechanisms of Action of the Peptide Toxins Targeting Human and Rodent Acid-Sensing Ion Channels and Relevance to Their In Vivo Analgesic Effects

Toxins 2022 Oct 17;14(10):709.doi: 10.3390/toxins14100709. Clément Verkest, Miguel Salinas, Sylvie Diochot, Emmanuel Deval, Eric Lingueglia, Anne Baron Abstract Acid-sensing ion channels (ASICs) are voltage-independent H+-gated cation channels largely expressed in the nervous system of rodents and humans. At least six isoforms (ASIC1a, 1b, 2a, 2b,

Better Fields or Currents? A Head-to-Head Comparison of Transcranial Magnetic (rTMS) Versus Direct Current Stimulation (tDCS) for Neuropathic Pain

Neurotherapeutics Randomized Controlled Trial . 2023 Jan;20(1):207-219.  doi: 10.1007/s13311-022-01303-x. Epub 2022 Oct 20. Nathalie André-Obadia, Hasan Hodaj, Enkelejda Hodaj, Emile Simon, Chantal Delon-Martin, Luis Garcia-Larrea Abstract While high-frequency transcranial magnetic stimulation (HF-rTMS) is now included in the armamentarium to treat chronic neuropathic pain (NP), direct-current anodal

Combining Awake Anesthesia with Minimal Invasive Surgery Optimizes Intraoperative Surgical Spinal Cord Stimulation Lead Placement

Journal of clinical medicine . 2022 Sep 22;11(19):5575. doi: 10.3390/jcm11195575. Philippe Rigoard, Amine Ounajim, Lisa Goudman, Chantal Wood, Manuel Roulaud, Philippe Page, Bertille Lorgeoux, Sandrine Baron, Kevin Nivole, Mathilde Many, Emmanuel Cuny, Jimmy Voirin, Denys Fontaine, Sylvie Raoul, Patrick Mertens, Philippe Peruzzi, François Caire, Nadia Buisset, Romain David, Maarten Moens, Maxime Billot Abstract Spinal cord stimulation (SCS) is an effective

Effectiveness of onabotulinumtoxinA (BOTOX®) for the preventive treatment of chronic migraine: A meta-analysis on 10 years of real-world data

Cephalalgia 2022 Sep 8;3331024221123058. doi: 10.1177/03331024221123058. Online ahead of print. Michel Lanteri-Minet, Anne Ducros , Clement Francois, Elzbieta Olewinska, Mateusz Nikodem, Laure Dupont-Benjamin Abstract Background: This meta-analysis evaluated the real-world effectiveness of onabotulinumtoxinA (BOTOX®), the first preventive treatment FDA-approved specifically for chronic migraine in 2010.

IMI2-PainCare-BioPain-RCT2 protocol: a randomized, double-blind, placebo-controlled, crossover, multicenter trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by non-invasive neurophysiological measurements of human spinal cord and brainstem activity

Trials 2022 Sep 5;23(1):739. doi: 10.1186/s13063-022-06431-5. Caterina Leone1, Giulia Di Stefano, Giuseppe Di Pietro, Petra Bloms-Funke, Irmgard Boesl , Ombretta Caspani , Sonya C Chapman, Nanna Brix Finnerup, Luis Garcia-Larrea, Tom Li, Marcus Goetz, André Mouraux, Bernhard Pelz, Esther Pogatzki-Zahn, Andreas Schilder, Erik Schnetter, Karin Schubart , Irene Tracey , Inaki F Troconiz, Hans Van Niel, Jose Miguel Vela Hernandez, Katy

Treatment of Chronic Refractory Pain by Combined Deep Brain Stimulation of the Anterior Cingulum and Sensory Thalamus (EMOPAIN Study): Rationale and Protocol of a Feasibility and Safety Study

Brain sciences 2022 Aug 23;12(9):1116. Aurélie Leplus, Michel Lanteri-Minet, Anne Donnet, Nelly Darmon, Jean Regis, Denys Fontaine Abstract Background: Deep Brain Stimulation (DBS) of the sensory thalamus has been proposed for 40 years to treat medically refractory neuropathic pain, but its efficacy remains partial and