Brain, Behavior, and Immunity 2024 Jul:119:750-766. doi: 10.1016/j.bbi.2024.05.010. Epub 2024 May 4. Ana Reynders, Z Anissa Jhumka, Stéphane Gaillard, Annabelle Mantilleri, Pascale Malapert, Karine Magalon, Anders Etzerodt, Chiara Salio, Sophie Ugolini, Francis Castets, Andrew J Saurin, Matteo Serino, Guillaume Hoeffel, Aziz Moqrich Abstract Chronic pain is a heavily debilitating condition and a huge socio-economic
A novel Nav1.8-FLPo driver mouse for intersectional genetics to uncover the functional significance of primary sensory neuron diversity
iScience 2024 Mar 5;27(4):109396. doi: 10.1016/j.isci.2024.109396. eCollection 2024 Apr 19. Pascale Malapert, Guillaume Robert, Elena Brunet, Jean Chemin, Emmanuel Bourinet, Aziz Moqrich Abstract The recent development of single-cell and single-nucleus RNA sequencing has highlighted the extraordinary diversity of dorsal root ganglia neurons. However, the few available
Sex-related exacerbation of injury-induced mechanical hypersensitivity in GAD67 haplodeficient mice
Pain 2024 Jan 1;165(1):192-201. doi: 10.1097/j.pain.0000000000003012. Epub 2023 Aug 11. Aude Charron, Lucie Pepino, Pascale Malapert, Vincent Debrauwer, Francis Castets, Chiara Salio, Aziz Moqrich Abstract Decreased GABA levels in injury-induced loss of spinal inhibition are still under intense interest and debate. Here, we show that GAD67 haplodeficient
Formalin-evoked pain triggers sex-specific behavior and spinal immune response
Scientific reports 2023 Jun 12;13(1):9515. doi: 10.1038/s41598-023-36245-7 Lucie Pepino, Pascale Malapert, Andrew J Saurin, Aziz Moqrich, Ana Reynders Abstract Mounting evidence shows sex-related differences in the experience of pain with women suffering more from chronic pain than men. Yet, our understanding of the biological