An ankyrin G-binding motif mediates TRAAK periodic localization at axon initial segments of hippocampal pyramidal neurons

Proceedings of the National Academy of Sciences of the United States of America 2024 Jul 30;121(31):e2310120121.  doi: 10.1073/pnas.2310120121. Epub 2024 Jul 26. Virginia Luque-Fernández 1, Sam K Vanspauwen 1, Arnaud Landra-Willm 2 3 4, Emil Arvedsen 1, Maïlys Besquent 2 3 4, Guillaume Sandoz 2 3 4, Hanne B Rasmussen 1 Abstract The axon initial segment (AIS) is a critical

A photoswitchable inhibitor of TREK channels controls pain in wild-type intact freely moving animals

Nature communications . 2023 Mar 1;14(1):1160. doi: 10.1038/s41467-023-36806-4. Arnaud Landra-Willm, Ameya Karapurkar, Alexia Duveau, Anne Amandine Chassot, Lucille Esnault, Gerard Callejo, Marion Bied, Stephanie Häfner, Florian Lesage, Brigitte Wdziekonski, Anne Baron, Pascal Fossat, Laurent Marsollier, Xavier Gasull, Eric Boué-Grabot, Michael A Kienzler, Guillaume Sandoz Abstract By endowing light control of neuronal activity, optogenetics and photopharmacology are

Regulation of two-pore-domain potassium TREK channels and their involvement in pain perception and migraine

Neuroscience letters 2022 Mar 16;773:136494 doi: 10.1016/j.neulet.2022.136494. Epub 2022 Jan 31. Pablo Ávalos Prado, Anne-Amandine Chassot, Arnaud Landra-Willm, Guillaume Sandoz Abstract The ability to sense pain signals is closely linked to the activity of ion channels expressed in nociceptors, the first neurons that

TREK channel activation suppresses migraine pain phenotype

iScience 2021 Aug 8;24(9):102961 doi: 10.1016/j.isci.2021.102961. eCollection 2021 Sep 24. Pablo Ávalos Prado , Arnaud Landra-Willm , Clément Verkest  , Aurore Ribera  , Anne-Amandine Chassot  , Anne Baron  , Guillaume Sandoz. Abstract Activation and sensitization of trigeminal ganglia (TG) sensory neurons, leading to the release of

Migraine and Two-Pore-Domain Potassium Channels

The Neuroscientist. 2020 Jul 27;1073858420940949. doi: 10.1177/1073858420940949. Online ahead of print. Migraine and Two-Pore-Domain Potassium Channels Clément Verkest, Stephanie Häfner, Pablo Ávalos Prado, Anne Baron, Guillaume Sandoz PMID: 32715910 DOI: 10.1177/1073858420940949 Abstract Migraine is a common, disabling neurological disorder with a genetic, environmental, and

Two-pore-domain potassium channels and molecular mechanisms underlying migraine

Biologie Aujourd’hui 2019;213(1-2):51-57. doi: 10.1051/jbio/2019020. Epub 2019 Jul 5. [Two-pore-domain potassium channels and molecular mechanisms underlying migraine] Perrine Royal, Pablo Ávalos Prado, Brigitte Wdziekonski, Guillaume Sandoz PMID: 31274103 DOI: 10.1051/jbio/2019020 Abstract Migraine is a common, disabling neurological disorder with genetic, environmental and hormonal