Reduced Codeine Analgesic Efficacy Associated with Nicardipine in a Patient with Medication-Overuse Headache: A Case Report

Journal of pain & palliative care pharmacotherapy Vincent Arcani, Nicolas Fabresse, Guillaume Hache, Anne Donnet Abstract Codeine is a prodrug opioid whose analgesic efficacy depends on its bioactivation into morphine via cytochrome P450 2D6. Its use in migraine is discouraged because of limited