European Journal of Pain 2022 Mar 30 doi: 10.1002/ejp.1948. Online ahead of print. Denys Fontaine, Valentin Vielzeuf, Philippe Genestier, Pascal Limeux, Serena Santucci-Sivilotto, Emmanuel Mory, Nelly Darmon, Michel Lanteri-Minet, May Mokhtar, Melanie Laine, Damien Vistoli, DEFI study group Abstract Background: Pain intensity evaluation by self-report is difficult and biased in
Regulation of two-pore-domain potassium TREK channels and their involvement in pain perception and migraine
Neuroscience letters 2022 Mar 16;773:136494 doi: 10.1016/j.neulet.2022.136494. Epub 2022 Jan 31. Pablo Ávalos Prado, Anne-Amandine Chassot, Arnaud Landra-Willm, Guillaume Sandoz Abstract The ability to sense pain signals is closely linked to the activity of ion channels expressed in nociceptors, the first neurons that
C-Jun N-Terminal Kinase Post-Translational Regulation of Pain-Related Acid-Sensing Ion Channels 1b and 3
The Journal of neuroscience : the official journal of the Society for Neuroscience 2021 Oct 20;41(42):8673-8685 doi: 10.1523/JNEUROSCI.0570-21.2021. Epub 2021 Aug 11. Clément Verkest , Sylvie Diochot, Eric Lingueglia, Anne Baron Abstract Neuronal proton-gated acid-sensing ion channels (ASICs) participate in the detection of
Fluorescent- and tagged-protoxin II peptides: potent markers of the Na v 1.7 channel pain target
British journal of pharmacology 2021 Jul;178(13):2632-2650 doi: 10.1111/bph.15453. Epub 2021 May 14. Jérôme Montnach , Stephan De Waard, Sébastien Nicolas, Sophie Burel, Nancy Osorio, Claude Zoukimian, Massimo Mantegazza, Rachid Boukaiba, Rémy Béroud, Michel Partiseti, Patrick Delmas, Céline Marionneau, Michel De Waard Abstract Background and purpose: Protoxin II (ProTx II) is a high
Severe migraine and its control: A proposal for definitions and consequences for care
Revue Neurologique 2021 Mar 30; doi: 10.1016/j.neurol.2020.11.012. Anne Donnet , Anne Ducros , Françoise Radat , Bashar Allaf , Isabelle Chouette , Michel Lanteri-Minet Abstract Currently many patients with severe migraine do not receive appropriate treatment and are never referred to specialist headache centres.
Mambalgin-1 pain-relieving peptide locks the hinge between α4 and α5 helices to inhibit rat acid-sensing ion channel 1a
Neuropharmacology 2021 Mar 1;185:108453. doi: 10.1016/j.neuropharm.2021.108453. Epub 2021 Jan 12. Miguel Salinas, Pascal Kessler, Dominique Douguet, Daad Sarraf, Nicolo Tonali, Robert Thai, Denis Servent, Eric Lingueglia Abstract Acid-sensing ion channels (ASICs) are proton-gated cationic channels involved in pain and other processes, underscoring the potential therapeutic value of
Migraine-Associated TRESK Mutations Increase Neuronal Excitability through Alternative Translation Initiation and Inhibition of TREK.
Neuron. 2019 Jan 16;101(2):232-245.e6. doi: 10.1016/j.neuron.2018.11.039. Epub 2018 Dec 17. Royal P1, Andres-Bilbe A2, Ávalos Prado P1, Verkest C3, Wdziekonski B1, Schaub S4, Baron A5, Lesage F3, Gasull X2, Levitz J6, Sandoz G7. Abstract It is often unclear why some
Efficacy and tolerability of erenumab in patients with episodic migraine in whom two-to-four previous preventive treatments were unsuccessful: a randomised, double-blind, placebo-controlled, phase 3b study.
Lancet. 2018 Nov 24;392(10161):2280-2287. doi: 10.1016/S0140-6736(18)32534-0. Epub 2018 Oct 22. Reuter U1, Goadsby PJ2, Lanteri-Minet M3, Wen S4, Hours-Zesiger P5, Ferrari MD6, Klatt J5. Abstract BACKGROUND: A substantial proportion of patients with migraine does not respond to, or cannot tolerate,
My Migraine Voice survey: a global study of disease burden among individuals with migraine for whom preventive treatments have failed.
J Headache Pain. 2018 Nov 27;19(1):115. doi: 10.1186/s10194-018-0946-z. Martelletti P1,2, Schwedt TJ3, Lanteri-Minet M4, Quintana R5, Carboni V6, Diener HC7, Ruiz de la Torre E8, Craven A9, Rasmussen AV10, Evans S11, Laflamme AK12, Fink R12, Walsh D13, Dumas P14, Vo
Dural and pial pain-sensitive structures in humans: new inputs from awake craniotomies.
Brain. 2018 Jan 29. doi: 10.1093/brain/awy005. [Epub ahead of print] Fontaine D1,2, Almairac F1, Santucci S1,2, Fernandez C1, Dallel R3, Pallud J4,5,6, Lanteri-Minet M2,3,7. Abstract Our knowledge on intracranial pain-sensitive structures in humans comes essentially from observations during neurosurgical procedures