Neuroscience letters 2022 Mar 16;773:136494 doi: 10.1016/j.neulet.2022.136494. Epub 2022 Jan 31. Pablo Ávalos Prado, Anne-Amandine Chassot, Arnaud Landra-Willm, Guillaume Sandoz Abstract The ability to sense pain signals is closely linked to the activity of ion channels expressed in nociceptors, the first neurons that
Initiation of migraine-related cortical spreading depolarization by hyperactivity of GABAergic neurons and NaV1.1 channels
The Journal of clinical investigation 2021 Nov 01;131(21):e142203. doi: 10.1172/JCI142203. Oana Chever, Sarah Zerimech, Paolo Scalmani, Louisiane Lemaire, Lara Pizzamiglio, Alexandre Loucif, Marion Ayrault, Martin Krupa, Mathieu Desroches, Fabrice Duprat, Isabelle Léna, Sandrine Cestèle, Massimo Mantegazza Abstract Spreading depolarizations (SDs) are involved in migraine, epilepsy, stroke, traumatic brain injury, and subarachnoid hemorrhage.
C-Jun N-Terminal Kinase Post-Translational Regulation of Pain-Related Acid-Sensing Ion Channels 1b and 3
The Journal of neuroscience : the official journal of the Society for Neuroscience 2021 Oct 20;41(42):8673-8685 doi: 10.1523/JNEUROSCI.0570-21.2021. Epub 2021 Aug 11. Clément Verkest , Sylvie Diochot, Eric Lingueglia, Anne Baron Abstract Neuronal proton-gated acid-sensing ion channels (ASICs) participate in the detection of
Modeling NaV1.1/SCN1A sodium channel mutations in a microcircuit with realistic ion concentration dynamics suggests differential GABAergic mechanisms leading to hyperexcitability in epilepsy and hemiplegic migraine
PLoS computational biology 2021 Jul 27;17(7):e1009239. doi: 10.1371/journal.pcbi.1009239. eCollection 2021 Jul. Louisiane Lemaire, Mathieu Desroches, Martin Krupa, Lara Pizzamiglio, Paolo Scalmani , Massimo Mantegazza Abstract Loss of function mutations of SCN1A, the gene coding for the voltage-gated sodium channel NaV1.1, cause different types of epilepsy,
Fluorescent- and tagged-protoxin II peptides: potent markers of the Na v 1.7 channel pain target
British journal of pharmacology 2021 Jul;178(13):2632-2650 doi: 10.1111/bph.15453. Epub 2021 May 14. Jérôme Montnach , Stephan De Waard, Sébastien Nicolas, Sophie Burel, Nancy Osorio, Claude Zoukimian, Massimo Mantegazza, Rachid Boukaiba, Rémy Béroud, Michel Partiseti, Patrick Delmas, Céline Marionneau, Michel De Waard Abstract Background and purpose: Protoxin II (ProTx II) is a high
Migraine and Two-Pore-Domain Potassium Channels
The Neuroscientist. 2020 Jul 27;1073858420940949. doi: 10.1177/1073858420940949. Online ahead of print. Migraine and Two-Pore-Domain Potassium Channels Clément Verkest, Stephanie Häfner, Pablo Ávalos Prado, Anne Baron, Guillaume Sandoz PMID: 32715910 DOI: 10.1177/1073858420940949 Abstract Migraine is a common, disabling neurological disorder with a genetic, environmental, and
Two-pore-domain potassium channels and molecular mechanisms underlying migraine
Biologie Aujourd’hui 2019;213(1-2):51-57. doi: 10.1051/jbio/2019020. Epub 2019 Jul 5. [Two-pore-domain potassium channels and molecular mechanisms underlying migraine] Perrine Royal, Pablo Ávalos Prado, Brigitte Wdziekonski, Guillaume Sandoz PMID: 31274103 DOI: 10.1051/jbio/2019020 Abstract Migraine is a common, disabling neurological disorder with genetic, environmental and hormonal
Migraine-Associated TRESK Mutations Increase Neuronal Excitability through Alternative Translation Initiation and Inhibition of TREK.
Neuron. 2019 Jan 16;101(2):232-245.e6. doi: 10.1016/j.neuron.2018.11.039. Epub 2018 Dec 17. Royal P1, Andres-Bilbe A2, Ávalos Prado P1, Verkest C3, Wdziekonski B1, Schaub S4, Baron A5, Lesage F3, Gasull X2, Levitz J6, Sandoz G7. Abstract It is often unclear why some
Effects of systemic inhibitors of Acid-Sensing Ion Channels 1 (ASIC1) against acute and chronic mechanical allodynia in a rodent model of migraine.
Br J Pharmacol. 2018 Nov;175(21):4154-4166. doi: 10.1111/bph.14462. Epub 2018 Sep 22. Verkest C1,2,3, Piquet E3,4, Diochot S1,2,3, Dauvois M1, Lanteri-Minet M3,4,5, Lingueglia E1,2,3, Baron A1,2,3. Abstract BACKGROUND AND PURPOSE: Acid-sensing ion channels (ASICs) are neuronal proton sensors emerging as potential
Gain of Function for the SCN1A/hNav1.1-L1670W Mutation Responsible for Familial Hemiplegic Migraine.
Front Mol Neurosci. 2018 Jul 9;11:232. doi: 10.3389/fnmol.2018.00232. eCollection 2018. Dhifallah S1, Lancaster E2, Merrill S2, Leroudier N1, Mantegazza M1, Cestèle S1. Author information Abstract The SCN1A gene encodes for the voltage-dependent Nav1.1 Na+ channel, an isoform mainly expressed in