IMI2-PainCare-BioPain-RCT2 protocol: a randomized, double-blind, placebo-controlled, crossover, multicenter trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by non-invasive neurophysiological measurements of human spinal cord and brainstem activity

Trials 2022 Sep 5;23(1):739. doi: 10.1186/s13063-022-06431-5. Caterina Leone1, Giulia Di Stefano, Giuseppe Di Pietro, Petra Bloms-Funke, Irmgard Boesl , Ombretta Caspani , Sonya C Chapman, Nanna Brix Finnerup, Luis Garcia-Larrea, Tom Li, Marcus Goetz, André Mouraux, Bernhard Pelz, Esther Pogatzki-Zahn, Andreas Schilder, Erik Schnetter, Karin Schubart , Irene Tracey , Inaki F Troconiz, Hans Van Niel, Jose Miguel Vela Hernandez, Katy

Treatment of Chronic Refractory Pain by Combined Deep Brain Stimulation of the Anterior Cingulum and Sensory Thalamus (EMOPAIN Study): Rationale and Protocol of a Feasibility and Safety Study

Brain sciences 2022 Aug 23;12(9):1116. Aurélie Leplus, Michel Lanteri-Minet, Anne Donnet, Nelly Darmon, Jean Regis, Denys Fontaine Abstract Background: Deep Brain Stimulation (DBS) of the sensory thalamus has been proposed for 40 years to treat medically refractory neuropathic pain, but its efficacy remains partial and

Antibody-induced pain-like behavior and bone erosion: links to subclinical inflammation, osteoclast activity, and acid-sensing ion channel 3-dependent sensitization

Pain 2022 Aug 1;163(8):1542-1559.doi: 10.1097/j.pain.0000000000002543. Epub 2021 Nov 19. Alexandra Jurczak, Lauriane Delay, Julie Barbier, Nils Simon, Emerson Krock, Katalin Sandor , Nilesh M Agalave, Resti Rudjito, Gustaf Wigerblad, Katarzyna Rogóż, Arnaud Briat, Elisabeth Miot-Noirault, Arisai Martinez-Martinez, Dieter Brömme, Caroline Grönwall, Vivianne Malmström, Lars Klareskog, Spiro Khoury, Thierry Ferreira, Bonnie Labrum, Emmanuel Deval, Juan Miguel Jiménez-Andrade, Fabien Marchand, Camilla I Svensson Erratum in

Safety and efficacy of eptinezumab for migraine prevention in patients with two-to-four previous preventive treatment failures (DELIVER): a multi-arm, randomised, double-blind, placebo-controlled, phase 3b trial

The Lancet Neurology 2022 Jul;21(7):597-607 doi: 10.1016/S1474-4422(22)00185-5. Messoud Ashina, Michel Lanteri-Minet, Patricia Pozo-Rosich, Anders Ettrup, Cecilie Laurberg Christoffersen, Mette Krog Josiassen, Ravinder Phul, Bjørn Sperling Abstract Background: The monoclonal antibody eptinezumab, which targets calcitonin gene-related peptide, has shown migraine preventive effects starting the day following infusion and

Transcranial direct current stimulation of 3 cortical targets is no more effective than placebo as treatment for fibromyalgia: a double-blind sham-controlled clinical trial

Pain Randomized Controlled Trial 2022 Jul 1;163(7):e850-e861.  doi: 10.1097/j.pain.0000000000002493. Epub 2021 Sep 23. Noelia Samartin-Veiga, Marina Pidal-Miranda, Alberto J González-Villar, Claire Bradley, Luis Garcia-Larrea, Anthony T O’Brien, María T Carrillo-de-la-Peña  Abstract Transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and the dorsolateral prefrontal cortex

Single Subcutaneous Injection of Lysophosphatidyl-Choline Evokes ASIC3-Dependent Increases of Spinal Dorsal Horn Neuron Activity

Frontiers in molecular neuroscience 2022 Jun 14;15:880651 doi: 10.3389/fnmol.2022.880651. eCollection 2022. Ludivine Pidoux, Kevin Delanoe, Julie Barbier, Fabien Marchand, Eric Lingueglia, Emmanuel Deval Abstract Lysophosphatidyl-choline (LPC), a member of the phospholipid family, is an emerging player in pain. It is known to modulate different pain-related

Occipital Nerve Stimulation for Recurrent Trigeminal Neuralgia Without Occipital Pain

Neuromodulation : Journal of the International Neuromodulation Society 2022 Jun 7;S1094-7159(22)00649-3. doi: 10.1016/j.neurom.2022.03.012. Online ahead of print. Anne Balossier, Anne Donnet, Jean Régis, Aurélie Leplus , Michel Lantéri-Minet, Denys Fontaine Abstract Objectives: Trigeminal neuralgia (TN) is a severe, debilitating pain condition causing physical and emotional

Calcitonin gene-related peptide-targeting drugs and Raynaud’s phenomenon: a real-world potential safety signal from the WHO pharmacovigilance database

The journal of headache and pain 2022 May 3;23(1):53 doi: 10.1186/s10194-022-01424-w. Alexandre O Gérard, Diane Merino, Elise K Van Obberghen, Fanny Rocher, Alexandre Destere, Michel Lantéri-Minet, Milou-Daniel Drici Abstract Background: Migraine is responsible for significant disability and societal burden. Recently, drugs targeting the calcitonin gene-related peptide

Practice guidelines for the treatment of acute migraine and chronic knee osteoarthritis with paracetamol: an expert appraisal on evolution over time between scientific societies

Current Medical Research and Opinion 2022 May 13;1-18 doi: 10.1080/03007995.2022.2076475. Online ahead of print. Serge Perrot, Alain Eschalier, Jules Desmeules, Michel Lanteri-Minet, Nadine Attal Abstract Background: Paracetamol is the commonest analgesic worldwide in primary care. Despite evidence-based recommendations for management of acute and chronic

Artificial intelligence to evaluate postoperative pain based on facial expression recognition

European Journal of Pain 2022 Mar 30   doi: 10.1002/ejp.1948. Online ahead of print. Denys Fontaine, Valentin Vielzeuf, Philippe Genestier, Pascal Limeux, Serena Santucci-Sivilotto, Emmanuel Mory, Nelly Darmon, Michel Lanteri-Minet, May Mokhtar, Melanie Laine, Damien Vistoli, DEFI study group Abstract Background: Pain intensity evaluation by self-report is difficult and biased in