One-year prospective real-world assessment of effectiveness and safety of erenumab in migraine prevention: results of the French FHU INOVPAIN registry study

The Journal of Headache and Pain 2023 Nov 8;24(1):152. doi: 10.1186/s10194-023-01680-4. M Lanteri-Minet, R Fabre, C Martin, K Pradat, A Alchaar, E Bozzolo, M L Duchene, E K Van Obberghen, A Donnet, D Fontaine Abstract Background: Randomized clinical trials have

Pain in Parkinson disease: mechanistic substrates, main classification systems, and how to make sense out of them

Pain 2023 Nov 1;164(11):2425-2434. doi: 10.1097/j.pain.0000000000002968. Epub 2023 Jun 6. Daniel Ciampi de Andrade, Veit Mylius, Santiago Perez-Lloret, Rubens G Cury, Kirsty Bannister, Xavier Moisset, Gabriel Taricani Kubota, Nanna B Finnerup, Didier Bouhassira, Kallol Ray Chaudhuri, Thomas Graven-Nielsen, Rolf-Detlef Treede Abstract Parkinson disease (PD) affects up to 2% of the general

Acid-sensing ion channel 3 mediates pain hypersensitivity associated with high-fat diet consumption in mice

Pain 2023 Sep 21.doi: 10.1097/j.pain.0000000000003030. Online ahead of print. Ahmed Negm, Katharina Stobbe, Selma Ben Fradj, Clara Sanchez, Arnaud Landra-Willm, Margaux Richter, Lucile Fleuriot, Delphine Debayle, Emmanuel Deval, Eric Lingueglia, Carole Rovere, Jacques Noel   Abstract Lipid-rich diet is the major cause of obesity, affecting 13% of the worldwide adult

Dual contribution of ASIC1a channels in the spinal processing of pain information by deep projection neurons revealed by computational modeling

PLoS computational biology 2023 Apr 17;19(4):e1010993.doi: 10.1371/journal.pcbi.1010993. eCollection 2023 Apr. Magda Chafaï, Ariane Delrocq, Perrine Inquimbert, Ludivine Pidoux, Kevin Delanoe, Maurizio Toft, Frederic Brau, Eric Lingueglia, Romain Veltz, Emmanuel Deval Abstract Dorsal horn of the spinal cord is an important crossroad of pain neuraxis, especially for the neuronal plasticity

A photoswitchable inhibitor of TREK channels controls pain in wild-type intact freely moving animals

Nature communications . 2023 Mar 1;14(1):1160. doi: 10.1038/s41467-023-36806-4. Arnaud Landra-Willm, Ameya Karapurkar, Alexia Duveau, Anne Amandine Chassot, Lucille Esnault, Gerard Callejo, Marion Bied, Stephanie Häfner, Florian Lesage, Brigitte Wdziekonski, Anne Baron, Pascal Fossat, Laurent Marsollier, Xavier Gasull, Eric Boué-Grabot, Michael A Kienzler, Guillaume Sandoz Abstract By endowing light control of neuronal activity, optogenetics and photopharmacology are

Mechanisms of Action of the Peptide Toxins Targeting Human and Rodent Acid-Sensing Ion Channels and Relevance to Their In Vivo Analgesic Effects

Toxins 2022 Oct 17;14(10):709.doi: 10.3390/toxins14100709. Clément Verkest, Miguel Salinas, Sylvie Diochot, Emmanuel Deval, Eric Lingueglia, Anne Baron Abstract Acid-sensing ion channels (ASICs) are voltage-independent H+-gated cation channels largely expressed in the nervous system of rodents and humans. At least six isoforms (ASIC1a, 1b, 2a, 2b,

Single Subcutaneous Injection of Lysophosphatidyl-Choline Evokes ASIC3-Dependent Increases of Spinal Dorsal Horn Neuron Activity

Frontiers in molecular neuroscience 2022 Jun 14;15:880651 doi: 10.3389/fnmol.2022.880651. eCollection 2022. Ludivine Pidoux, Kevin Delanoe, Julie Barbier, Fabien Marchand, Eric Lingueglia, Emmanuel Deval Abstract Lysophosphatidyl-choline (LPC), a member of the phospholipid family, is an emerging player in pain. It is known to modulate different pain-related

Artificial intelligence to evaluate postoperative pain based on facial expression recognition

European Journal of Pain 2022 Mar 30   doi: 10.1002/ejp.1948. Online ahead of print. Denys Fontaine, Valentin Vielzeuf, Philippe Genestier, Pascal Limeux, Serena Santucci-Sivilotto, Emmanuel Mory, Nelly Darmon, Michel Lanteri-Minet, May Mokhtar, Melanie Laine, Damien Vistoli, DEFI study group Abstract Background: Pain intensity evaluation by self-report is difficult and biased in