Pmu1a, a novel spider toxin with dual inhibitory activity at pain targets hNaV 1.7 and hCaV 3 voltage-gated channels

The FEBS journal 2023 Jul;290(14):3688-3702. doi: 10.1111/febs.16773. Epub 2023 Mar 23. Julien Giribaldi, Jean Chemin, Marie Tuifua, Jennifer R Deuis, Rosanna Mary, Irina Vetter, David T Wilson, Norelle L Daly, Christina I Schroeder, Emmanuel Bourinet, Sébastien Dutertre Abstract Venom-derived peptides targeting ion channels involved in pain are regarded as a promising

Single Subcutaneous Injection of Lysophosphatidyl-Choline Evokes ASIC3-Dependent Increases of Spinal Dorsal Horn Neuron Activity

Frontiers in molecular neuroscience 2022 Jun 14;15:880651 doi: 10.3389/fnmol.2022.880651. eCollection 2022. Ludivine Pidoux, Kevin Delanoe, Julie Barbier, Fabien Marchand, Eric Lingueglia, Emmanuel Deval Abstract Lysophosphatidyl-choline (LPC), a member of the phospholipid family, is an emerging player in pain. It is known to modulate different pain-related

TREK channel activation suppresses migraine pain phenotype

iScience 2021 Aug 8;24(9):102961 doi: 10.1016/j.isci.2021.102961. eCollection 2021 Sep 24. Pablo Ávalos Prado , Arnaud Landra-Willm , Clément Verkest  , Aurore Ribera  , Anne-Amandine Chassot  , Anne Baron  , Guillaume Sandoz. Abstract Activation and sensitization of trigeminal ganglia (TG) sensory neurons, leading to the release of