Proceedings of the National Academy of Sciences of the United States of America 2024 Jul 30;121(31):e2310120121. doi: 10.1073/pnas.2310120121. Epub 2024 Jul 26. Virginia Luque-Fernández 1, Sam K Vanspauwen 1, Arnaud Landra-Willm 2 3 4, Emil Arvedsen 1, Maïlys Besquent 2 3 4, Guillaume Sandoz 2 3 4, Hanne B Rasmussen 1 Abstract The axon initial segment (AIS) is a critical
Gut microbiota promotes pain chronicity in Myosin1A deficient male mice
Brain, Behavior, and Immunity 2024 Jul:119:750-766. doi: 10.1016/j.bbi.2024.05.010. Epub 2024 May 4. Ana Reynders, Z Anissa Jhumka, Stéphane Gaillard, Annabelle Mantilleri, Pascale Malapert, Karine Magalon, Anders Etzerodt, Chiara Salio, Sophie Ugolini, Francis Castets, Andrew J Saurin, Matteo Serino, Guillaume Hoeffel, Aziz Moqrich Abstract Chronic pain is a heavily debilitating condition and a huge socio-economic
Parvalbumin gates chronic pain through the modulation of firing patterns in inhibitory neurons
Proceedings of the National Academy of Sciences of the United States of America 2024 Jul 2;121(27):e2403777121. doi: 10.1073/pnas.2403777121. Epub 2024 Jun 25. Haoyi Qiu, Loïs S Miraucourt, Hugues Petitjean, Mengyi Xu, Catherine Theriault, Albena Davidova, Vanessa Soubeyre, Gaetan Poulen, Nicolas Lonjon, Florence Vachiery-Lahaye, Luc Bauchet, Philipa Levesque-Damphousse, Jennifer L Estall, Emmanuel Bourinet, Reza Sharif-Naeini Abstract
Novel Scorpion Toxin ω-Buthitoxin-Hf1a Selectively Inhibits Calcium Influx via CaV3.3 and CaV3.2 and Alleviates Allodynia in a Mouse Model of Acute Postsurgical Pain
International Journal of Molecular Sciences 2024 Apr 26;25(9):4745. doi: 10.3390/ijms25094745. Dan Wang, Volker Herzig, Zoltan Dekan, K Johan Rosengren, Colton D Payne, Md Mahadhi Hasan, Jiajie Zhuang, Emmanuel Bourinet, Lotten Ragnarsson, Paul F Alewood, Richard J Lewis Abstract Venom peptides have evolved to target a wide range of membrane proteins
Induction of antiviral interferon-stimulated genes by neuronal STING promotes the resolution of pain in mice
The Journal of clinical investigation . 2024 Mar 19;134(9):e176474. doi: 10.1172/JCI176474. Manon Defaye , Amyaouch Bradaia, Nasser S Abdullah, Francina Agosti, Mircea Iftinca, Mélissa Delanne-Cuménal, Vanessa Soubeyre, Kristofer Svendsen, Gurveer Gill, Aye Ozmaeian, Nadine Gheziel, Jérémy Martin, Gaetan Poulen, Nicolas Lonjon, Florence Vachiery-Lahaye, Luc Bauchet, Lilian Basso, Emmanuel Bourinet, Isaac M Chiu, Christophe Altier Abstract Inflammation and pain are intertwined
A novel Nav1.8-FLPo driver mouse for intersectional genetics to uncover the functional significance of primary sensory neuron diversity
iScience 2024 Mar 5;27(4):109396. doi: 10.1016/j.isci.2024.109396. eCollection 2024 Apr 19. Pascale Malapert, Guillaume Robert, Elena Brunet, Jean Chemin, Emmanuel Bourinet, Aziz Moqrich Abstract The recent development of single-cell and single-nucleus RNA sequencing has highlighted the extraordinary diversity of dorsal root ganglia neurons. However, the few available
Gut dysbiosis in patients with chronic pain: a systematic review and meta-analysis
Frontiers in immunology 2024 Jan 30:15:1342833. doi: 10.3389/fimmu.2024.1342833. eCollection 2024. Lisa Goudman, Thomas Demuyser, Julie G Pilitsis, Maxime Billot, Manuel Roulaud, Philippe Rigoard, Maarten Moens Abstract Introduction: Recent evidence supports the contribution of gut microbiota dysbiosis to the pathophysiology of rheumatic diseases, neuropathic pain, and neurodegenerative disorders. The
Sex-related exacerbation of injury-induced mechanical hypersensitivity in GAD67 haplodeficient mice
Pain 2024 Jan 1;165(1):192-201. doi: 10.1097/j.pain.0000000000003012. Epub 2023 Aug 11. Aude Charron, Lucie Pepino, Pascale Malapert, Vincent Debrauwer, Francis Castets, Chiara Salio, Aziz Moqrich Abstract Decreased GABA levels in injury-induced loss of spinal inhibition are still under intense interest and debate. Here, we show that GAD67 haplodeficient
Cold-evoked potentials in clinical practice: A head-to-head contrast with laser-evoked responses
European Journal of Pain 2023 Sep;27(8):1006-1022. doi: 10.1002/ejp.2142. Epub 2023 Jun 6. Caroline Perchet, Koichi Hagiwara, Charbel Salameh, Luis Garcia-Larrea Abstract Background: Innocuous cooling of the skin activates cold-specific Aδ fibres, and hence, the recording of cold-evoked potentials (CEPs) may improve the objective assessment of
Formalin-evoked pain triggers sex-specific behavior and spinal immune response
Scientific reports 2023 Jun 12;13(1):9515. doi: 10.1038/s41598-023-36245-7 Lucie Pepino, Pascale Malapert, Andrew J Saurin, Aziz Moqrich, Ana Reynders Abstract Mounting evidence shows sex-related differences in the experience of pain with women suffering more from chronic pain than men. Yet, our understanding of the biological