Acid-sensing ion channel 3 mediates pain hypersensitivity associated with high-fat diet consumption in mice

PAIN 2024 Feb 1;165(2):470-486. doi: 10.1097/j.pain.0000000000003030. Ahmed Negm, Katharina Stobbe, Selma Ben Fradj, Clara Sanchez, Arnaud Landra-Willm, Margaux Richter, Lucile Fleuriot, Delphine Debayle, Emmanuel Deval, Eric Lingueglia, Carole Rovere, Jacques Noel   Abstract Lipid-rich diet is the major cause of obesity, affecting 13% of the worldwide adult population. Obesity is a

Acid-sensing ion channel 3 mediates pain hypersensitivity associated with high-fat diet consumption in mice

Pain 2023 Sep 21.doi: 10.1097/j.pain.0000000000003030. Online ahead of print. Ahmed Negm, Katharina Stobbe, Selma Ben Fradj, Clara Sanchez, Arnaud Landra-Willm, Margaux Richter, Lucile Fleuriot, Delphine Debayle, Emmanuel Deval, Eric Lingueglia, Carole Rovere, Jacques Noel   Abstract Lipid-rich diet is the major cause of obesity, affecting 13% of the worldwide adult

Dual contribution of ASIC1a channels in the spinal processing of pain information by deep projection neurons revealed by computational modeling

PLoS computational biology 2023 Apr 17;19(4):e1010993.doi: 10.1371/journal.pcbi.1010993. eCollection 2023 Apr. Magda Chafaï, Ariane Delrocq, Perrine Inquimbert, Ludivine Pidoux, Kevin Delanoe, Maurizio Toft, Frederic Brau, Eric Lingueglia, Romain Veltz, Emmanuel Deval Abstract Dorsal horn of the spinal cord is an important crossroad of pain neuraxis, especially for the neuronal plasticity

Mechanisms of Action of the Peptide Toxins Targeting Human and Rodent Acid-Sensing Ion Channels and Relevance to Their In Vivo Analgesic Effects

Toxins 2022 Oct 17;14(10):709.doi: 10.3390/toxins14100709. Clément Verkest, Miguel Salinas, Sylvie Diochot, Emmanuel Deval, Eric Lingueglia, Anne Baron Abstract Acid-sensing ion channels (ASICs) are voltage-independent H+-gated cation channels largely expressed in the nervous system of rodents and humans. At least six isoforms (ASIC1a, 1b, 2a, 2b,

Single Subcutaneous Injection of Lysophosphatidyl-Choline Evokes ASIC3-Dependent Increases of Spinal Dorsal Horn Neuron Activity

Frontiers in molecular neuroscience 2022 Jun 14;15:880651 doi: 10.3389/fnmol.2022.880651. eCollection 2022. Ludivine Pidoux, Kevin Delanoe, Julie Barbier, Fabien Marchand, Eric Lingueglia, Emmanuel Deval Abstract Lysophosphatidyl-choline (LPC), a member of the phospholipid family, is an emerging player in pain. It is known to modulate different pain-related

Lysophosphatidylcholine 16: 0 mediates chronic joint pain associated to rheumatic diseases through acid-sensing ion channel 3

Pain 2022 Jan 27 doi: 10.1097/j.pain.0000000000002596. Online ahead of print. Florian Jacquot , Spiro Khoury, Bonnie Labrum, Kévin Delanoe, Ludivine Pidoux, Julie Barbier, Lauriane Delay, Agathe Bayle, Youssef Aissouni, David A Barriere, Kim Kultima, Eva Freyhult, Anders Hugo, Eva Kosek, Aisha S Ahmed, Alexandra Jurczak, Eric Lingueglia, Camilla I Svensson, Véronique Breuil, Thierry Ferreira, Fabien Marchand, Emmanuel Deval Abstract Rheumatic diseases

C-Jun N-Terminal Kinase Post-Translational Regulation of Pain-Related Acid-Sensing Ion Channels 1b and 3

The Journal of neuroscience : the official journal of the Society for Neuroscience 2021 Oct 20;41(42):8673-8685 doi: 10.1523/JNEUROSCI.0570-21.2021. Epub 2021 Aug 11. Clément Verkest , Sylvie Diochot, Eric Lingueglia, Anne Baron Abstract Neuronal proton-gated acid-sensing ion channels (ASICs) participate in the detection of

Mambalgin-1 pain-relieving peptide locks the hinge between α4 and α5 helices to inhibit rat acid-sensing ion channel 1a

Neuropharmacology 2021 Mar 1;185:108453. doi: 10.1016/j.neuropharm.2021.108453. Epub 2021 Jan 12. Miguel Salinas, Pascal Kessler, Dominique Douguet, Daad Sarraf, Nicolo Tonali, Robert Thai, Denis Servent, Eric Lingueglia Abstract Acid-sensing ion channels (ASICs) are proton-gated cationic channels involved in pain and other processes, underscoring the potential therapeutic value of

Effects of systemic inhibitors of Acid-Sensing Ion Channels 1 (ASIC1) against acute and chronic mechanical allodynia in a rodent model of migraine.

Br J Pharmacol. 2018 Nov;175(21):4154-4166. doi: 10.1111/bph.14462. Epub 2018 Sep 22. Verkest C1,2,3, Piquet E3,4, Diochot S1,2,3, Dauvois M1, Lanteri-Minet M3,4,5, Lingueglia E1,2,3, Baron A1,2,3. Abstract BACKGROUND AND PURPOSE: Acid-sensing ion channels (ASICs) are neuronal proton sensors emerging as potential