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Novel Scorpion Toxin ω-Buthitoxin-Hf1a Selectively Inhibits Calcium Influx via CaV3.3 and CaV3.2 and Alleviates Allodynia in a Mouse Model of Acute Postsurgical Pain
International Journal of Molecular Sciences 2024 Apr 26;25(9):4745. doi: 10.3390/ijms25094745. Dan Wang, Volker Herzig, Zoltan Dekan, K Johan Rosengren, Colton D Payne, Md Mahadhi Hasan, Jiajie Zhuang, Emmanuel Bourinet, Lotten Ragnarsson, Paul F Alewood, Richard J Lewis Abstract Venom peptides have evolved to target a wide range of membrane proteins
Induction of antiviral interferon-stimulated genes by neuronal STING promotes the resolution of pain in mice
The Journal of clinical investigation . 2024 Mar 19;134(9):e176474. doi: 10.1172/JCI176474. Manon Defaye , Amyaouch Bradaia, Nasser S Abdullah, Francina Agosti, Mircea Iftinca, Mélissa Delanne-Cuménal, Vanessa Soubeyre, Kristofer Svendsen, Gurveer Gill, Aye Ozmaeian, Nadine Gheziel, Jérémy Martin, Gaetan Poulen, Nicolas Lonjon, Florence Vachiery-Lahaye, Luc Bauchet, Lilian Basso, Emmanuel Bourinet, Isaac M Chiu, Christophe Altier Abstract Inflammation and pain are intertwined
A novel Nav1.8-FLPo driver mouse for intersectional genetics to uncover the functional significance of primary sensory neuron diversity
iScience 2024 Mar 5;27(4):109396. doi: 10.1016/j.isci.2024.109396. eCollection 2024 Apr 19. Pascale Malapert, Guillaume Robert, Elena Brunet, Jean Chemin, Emmanuel Bourinet, Aziz Moqrich Abstract The recent development of single-cell and single-nucleus RNA sequencing has highlighted the extraordinary diversity of dorsal root ganglia neurons. However, the few available
Pmu1a, a novel spider toxin with dual inhibitory activity at pain targets hNaV 1.7 and hCaV 3 voltage-gated channels
The FEBS journal 2023 Jul;290(14):3688-3702. doi: 10.1111/febs.16773. Epub 2023 Mar 23. Julien Giribaldi, Jean Chemin, Marie Tuifua, Jennifer R Deuis, Rosanna Mary, Irina Vetter, David T Wilson, Norelle L Daly, Christina I Schroeder, Emmanuel Bourinet, Sébastien Dutertre Abstract Venom-derived peptides targeting ion channels involved in pain are regarded as a promising