Dual contribution of ASIC1a channels in the spinal processing of pain information by deep projection neurons revealed by computational modeling

PLoS computational biology 2023 Apr 17;19(4):e1010993.doi: 10.1371/journal.pcbi.1010993. eCollection 2023 Apr. Magda Chafaï, Ariane Delrocq, Perrine Inquimbert, Ludivine Pidoux, Kevin Delanoe, Maurizio Toft, Frederic Brau, Eric Lingueglia, Romain Veltz, Emmanuel Deval Abstract Dorsal horn of the spinal cord is an important crossroad of pain neuraxis, especially for the neuronal plasticity

Frontal headache in a patient with right temporal epilepsy: A video-EEG case report of ictal epileptic headache

Headache 2023 Mar;63(3):455-458.doi: 10.1111/head.14475. Epub 2023 Mar 10. Geneviève Demarquay, Emilie Sala, Ahmed Adham, Jean-Philippe Camdessanché, Philippe Convers, Laure Mazzola Abstract Background: Ictal epileptic headache (IEH) is caused by a focal epileptic seizure. The diagnosis can be challenging when the headache is isolated without any

Pmu1a, a novel spider toxin with dual inhibitory activity at pain targets hNaV 1.7 and hCaV 3 voltage-gated channels

The FEBS journal 2023 Jul;290(14):3688-3702. doi: 10.1111/febs.16773. Epub 2023 Mar 23. Julien Giribaldi, Jean Chemin, Marie Tuifua, Jennifer R Deuis, Rosanna Mary, Irina Vetter, David T Wilson, Norelle L Daly, Christina I Schroeder, Emmanuel Bourinet, Sébastien Dutertre Abstract Venom-derived peptides targeting ion channels involved in pain are regarded as a promising

A photoswitchable inhibitor of TREK channels controls pain in wild-type intact freely moving animals

Nature communications . 2023 Mar 1;14(1):1160. doi: 10.1038/s41467-023-36806-4. Arnaud Landra-Willm, Ameya Karapurkar, Alexia Duveau, Anne Amandine Chassot, Lucille Esnault, Gerard Callejo, Marion Bied, Stephanie Häfner, Florian Lesage, Brigitte Wdziekonski, Anne Baron, Pascal Fossat, Laurent Marsollier, Xavier Gasull, Eric Boué-Grabot, Michael A Kienzler, Guillaume Sandoz Abstract By endowing light control of neuronal activity, optogenetics and photopharmacology are

Identification of Lipid Biomarkers for Chronic Joint Pain Associated with Different Joint Diseases

Biomolecules 2023 Feb 9;13(2):342. doi: 10.3390/biom13020342. Spiro Khoury, Jenny Colas, Véronique Breuil, Eva Kosek, Aisha S Ahmed, Camilla I Svensson, Fabien Marchand, Emmanuel Deval, Thierry Ferreira Abstract Lipids, especially lysophosphatidylcholine LPC16:0, have been shown to be involved in chronic joint pain through the activation of acid-sensing ion

Guidelines of the International Headache Society for Controlled Clinical Trials in Cluster Headache

Cephalalgia 2022 Dec;42(14):1450-1466 doi: 10.1177/03331024221120266. Epub 2022 Oct 21. Jean Schoenen, Agneta Henriette Snoer, Roemer B Brandt, Rolf Fronczek, Diana Y Wei, Chin-Sang Chung, Hans-Christoph Diener, David W Dodick, Denys Fontaine, Peter J Goadsby, Manjit Singh Matharu, Arne May, James S McGinley, Stewart J Tepper, Rigmor Højland Jensen, Michel D Ferrari; IHS Standing Committee for Clinical

Sympathetic skin response as an objective tool to estimate stimulus-associated arousal in a human model of hyperalgesia

Neurophysiologie clinique = Clinical neurophysiology 2022 Nov;52(6):436-445. doi: 10.1016/j.neucli.2022.10.002. Epub 2022 Oct 26. Charbel Salameh, Caroline Perchet, Koichi Hagiwara, Luis Garcia-Larrea Abstract Background: Pain is a private experience, whose assessment relies on subjective self-reporting. Inaccurate communication renders pain evaluation unreliable in individuals with alteration of