Over-the-counter non steroidal anti-inflammatory medications: Focus on the management of acute pain

Therapies https://doi.org/10.1016/j.therap.2024.10.061 Ruxandra Burlacu, Venceslas Bourdin, Patrick Blin, Fabrice Camaioni, Béatrice Clairaz, Michel Lantéri-Minet, Françoise Laroche, François Raineri, Serge Perrot, Jean-Paul Stahl, Nicolas H. Thurin, Stéphane Mouly Abstract Non-steroidal anti-inflammatory drugs (NSAIDs) are the second most widely used class of

Efficacy of Atogepant in Chronic Migraine With and Without Acute Medication Overuse in the Randomized, Double-Blind, Phase 3 PROGRESS Trial

Neurology 2024 Jul 23;103(2):e209584.  doi: 10.1212/WNL.0000000000209584. Epub 2024 Jun 26. Peter J Goadsby, Deborah I Friedman, Dagny Holle-Lee, Genevieve Demarquay, Sait Ashina, Fumihiko Sakai, Brian Neel, Pranav Gandhi , Brett Dabruzzo, Jonathan H Smith, Yingyi Liu, Joel M Trugman Abstract Background and objectives: Atogepant is an oral, calcitonin gene-related peptide receptor antagonist approved

Gut microbiota promotes pain chronicity in Myosin1A deficient male mice

Brain, Behavior, and Immunity 2024 Jul:119:750-766. doi: 10.1016/j.bbi.2024.05.010. Epub 2024 May 4. Ana Reynders, Z Anissa Jhumka, Stéphane Gaillard, Annabelle Mantilleri, Pascale Malapert, Karine Magalon, Anders Etzerodt, Chiara Salio, Sophie Ugolini, Francis Castets, Andrew J Saurin, Matteo Serino, Guillaume Hoeffel, Aziz Moqrich Abstract Chronic pain is a heavily debilitating condition and a huge socio-economic

Parvalbumin gates chronic pain through the modulation of firing patterns in inhibitory neurons

Proceedings of the National Academy of Sciences of the United States of America 2024 Jul 2;121(27):e2403777121. doi: 10.1073/pnas.2403777121. Epub 2024 Jun 25. Haoyi Qiu, Loïs S Miraucourt, Hugues Petitjean, Mengyi Xu, Catherine Theriault, Albena Davidova, Vanessa Soubeyre, Gaetan Poulen, Nicolas Lonjon, Florence Vachiery-Lahaye, Luc Bauchet, Philipa Levesque-Damphousse, Jennifer L Estall, Emmanuel Bourinet, Reza Sharif-Naeini Abstract

Improved Outcomes and Therapy Longevity after Salvage Using a Novel Spinal Cord Stimulation System for Chronic Pain: Multicenter, Observational, European Case Series

Journal of Clinical Medicine 2024 Feb 14;13(4):1079. doi: 10.3390/jcm13041079. Philippe Rigoard, Maxime Billot, Renaud Bougeard, Jose Emilio Llopis, Sylvie Raoul, Georgios Matis, Jan Vesper, Hayat Belaïd  Abstract Spinal cord stimulation (SCS) is proven to effectively relieve chronic neuropathic pain. However, some implanted patients may face loss of efficacy

Examining the Type, Quality, and Content of Web-Based Information for People With Chronic Pain Interested in Spinal Cord Stimulation: Social Listening Study

Journal of Medical Internet Research 2024 Jan 30:26:e48599. doi: 10.2196/48599. Maarten Moens, Leen Van Doorslaer, Maxime Billot, Edgard Eeckman, Manuel Roulaud, Philippe Rigoard, Maaike Fobelets, Lisa Goudman  Abstract Background: The increased availability of web-based medical information has encouraged patients with chronic pain to seek health care information from

Gut dysbiosis in patients with chronic pain: a systematic review and meta-analysis

Frontiers in immunology 2024 Jan 30:15:1342833. doi: 10.3389/fimmu.2024.1342833. eCollection 2024. Lisa Goudman, Thomas Demuyser, Julie G Pilitsis, Maxime Billot, Manuel Roulaud, Philippe Rigoard, Maarten Moens  Abstract Introduction: Recent evidence supports the contribution of gut microbiota dysbiosis to the pathophysiology of rheumatic diseases, neuropathic pain, and neurodegenerative disorders. The

Beyond trial-and-error: Individualizing therapeutic transcranial neuromodulation for chronic pain

European Journal of Pain 2023 Oct;27(9):1065-1083.  doi: 10.1002/ejp.2164. Epub 2023 Aug 19. Daniel Ciampi de Andrade, Luís García-Larrea Abstract Background and objective: Repetitive transcranial magnetic stimulation (rTMS) applied to the motor cortex provides supplementary relief for some individuals with chronic pain who are