Headache 2023 Mar;63(3):455-458.doi: 10.1111/head.14475. Epub 2023 Mar 10. Geneviève Demarquay, Emilie Sala, Ahmed Adham, Jean-Philippe Camdessanché, Philippe Convers, Laure Mazzola Abstract Background: Ictal epileptic headache (IEH) is caused by a focal epileptic seizure. The diagnosis can be challenging when the headache is isolated without any
Amygdala and anterior insula control the passage from nociception to pain
Cerebral cortex 2023 Mar 21;33(7):3538-3547. doi: 10.1093/cercor/bhac290. Juliette Gélébart, Luis Garcia-Larrea, Maud Frot Abstract Activation of the spinothalamic system does not always result in a subjective pain perception. While the cerebral network processing nociception is relatively well known, the one underlying its
Pmu1a, a novel spider toxin with dual inhibitory activity at pain targets hNaV 1.7 and hCaV 3 voltage-gated channels
The FEBS journal 2023 Jul;290(14):3688-3702. doi: 10.1111/febs.16773. Epub 2023 Mar 23. Julien Giribaldi, Jean Chemin, Marie Tuifua, Jennifer R Deuis, Rosanna Mary, Irina Vetter, David T Wilson, Norelle L Daly, Christina I Schroeder, Emmanuel Bourinet, Sébastien Dutertre Abstract Venom-derived peptides targeting ion channels involved in pain are regarded as a promising
A photoswitchable inhibitor of TREK channels controls pain in wild-type intact freely moving animals
Nature communications . 2023 Mar 1;14(1):1160. doi: 10.1038/s41467-023-36806-4. Arnaud Landra-Willm, Ameya Karapurkar, Alexia Duveau, Anne Amandine Chassot, Lucille Esnault, Gerard Callejo, Marion Bied, Stephanie Häfner, Florian Lesage, Brigitte Wdziekonski, Anne Baron, Pascal Fossat, Laurent Marsollier, Xavier Gasull, Eric Boué-Grabot, Michael A Kienzler, Guillaume Sandoz Abstract By endowing light control of neuronal activity, optogenetics and photopharmacology are
Identification of Lipid Biomarkers for Chronic Joint Pain Associated with Different Joint Diseases
Biomolecules 2023 Feb 9;13(2):342. doi: 10.3390/biom13020342. Spiro Khoury, Jenny Colas, Véronique Breuil, Eva Kosek, Aisha S Ahmed, Camilla I Svensson, Fabien Marchand, Emmanuel Deval, Thierry Ferreira Abstract Lipids, especially lysophosphatidylcholine LPC16:0, have been shown to be involved in chronic joint pain through the activation of acid-sensing ion
Guidelines of the International Headache Society for Controlled Clinical Trials in Cluster Headache
Cephalalgia 2022 Dec;42(14):1450-1466 doi: 10.1177/03331024221120266. Epub 2022 Oct 21. Jean Schoenen, Agneta Henriette Snoer, Roemer B Brandt, Rolf Fronczek, Diana Y Wei, Chin-Sang Chung, Hans-Christoph Diener, David W Dodick, Denys Fontaine, Peter J Goadsby, Manjit Singh Matharu, Arne May, James S McGinley, Stewart J Tepper, Rigmor Højland Jensen, Michel D Ferrari; IHS Standing Committee for Clinical
Sympathetic skin response as an objective tool to estimate stimulus-associated arousal in a human model of hyperalgesia
Neurophysiologie clinique = Clinical neurophysiology 2022 Nov;52(6):436-445. doi: 10.1016/j.neucli.2022.10.002. Epub 2022 Oct 26. Charbel Salameh, Caroline Perchet, Koichi Hagiwara, Luis Garcia-Larrea Abstract Background: Pain is a private experience, whose assessment relies on subjective self-reporting. Inaccurate communication renders pain evaluation unreliable in individuals with alteration of
The teaching of headache medicine in France: A questionnaire-based study
Headache 2022 Oct;62(9):1177-1186. doi: 10.1111/head.14395. Epub 2022 Oct 6. Marion Beltramone, Sylvain Redon, Sara Fernandes, Anne Ducros, Alexandre Avouac, Anne Donnet Abstract Background: The treatment of patients with headache represents an important part of a neurologist’s activity. It requires sufficient
Mechanisms of Action of the Peptide Toxins Targeting Human and Rodent Acid-Sensing Ion Channels and Relevance to Their In Vivo Analgesic Effects
Toxins 2022 Oct 17;14(10):709.doi: 10.3390/toxins14100709. Clément Verkest, Miguel Salinas, Sylvie Diochot, Emmanuel Deval, Eric Lingueglia, Anne Baron Abstract Acid-sensing ion channels (ASICs) are voltage-independent H+-gated cation channels largely expressed in the nervous system of rodents and humans. At least six isoforms (ASIC1a, 1b, 2a, 2b,
Better Fields or Currents? A Head-to-Head Comparison of Transcranial Magnetic (rTMS) Versus Direct Current Stimulation (tDCS) for Neuropathic Pain
Neurotherapeutics Randomized Controlled Trial . 2023 Jan;20(1):207-219. doi: 10.1007/s13311-022-01303-x. Epub 2022 Oct 20. Nathalie André-Obadia, Hasan Hodaj, Enkelejda Hodaj, Emile Simon, Chantal Delon-Martin, Luis Garcia-Larrea Abstract While high-frequency transcranial magnetic stimulation (HF-rTMS) is now included in the armamentarium to treat chronic neuropathic pain (NP), direct-current anodal