Dual contribution of ASIC1a channels in the spinal processing of pain information by deep projection neurons revealed by computational modeling

PLoS computational biology 2023 Apr 17;19(4):e1010993.doi: 10.1371/journal.pcbi.1010993. eCollection 2023 Apr. Magda Chafaï, Ariane Delrocq, Perrine Inquimbert, Ludivine Pidoux, Kevin Delanoe, Maurizio Toft, Frederic Brau, Eric Lingueglia, Romain Veltz, Emmanuel Deval Abstract Dorsal horn of the spinal cord is an important crossroad of pain neuraxis, especially for the neuronal plasticity

Frontal headache in a patient with right temporal epilepsy: A video-EEG case report of ictal epileptic headache

Headache 2023 Mar;63(3):455-458.doi: 10.1111/head.14475. Epub 2023 Mar 10. Geneviève Demarquay, Emilie Sala, Ahmed Adham, Jean-Philippe Camdessanché, Philippe Convers, Laure Mazzola Abstract Background: Ictal epileptic headache (IEH) is caused by a focal epileptic seizure. The diagnosis can be challenging when the headache is isolated without any

Pmu1a, a novel spider toxin with dual inhibitory activity at pain targets hNaV 1.7 and hCaV 3 voltage-gated channels

The FEBS journal 2023 Jul;290(14):3688-3702. doi: 10.1111/febs.16773. Epub 2023 Mar 23. Julien Giribaldi, Jean Chemin, Marie Tuifua, Jennifer R Deuis, Rosanna Mary, Irina Vetter, David T Wilson, Norelle L Daly, Christina I Schroeder, Emmanuel Bourinet, Sébastien Dutertre Abstract Venom-derived peptides targeting ion channels involved in pain are regarded as a promising

A photoswitchable inhibitor of TREK channels controls pain in wild-type intact freely moving animals

Nature communications . 2023 Mar 1;14(1):1160. doi: 10.1038/s41467-023-36806-4. Arnaud Landra-Willm, Ameya Karapurkar, Alexia Duveau, Anne Amandine Chassot, Lucille Esnault, Gerard Callejo, Marion Bied, Stephanie Häfner, Florian Lesage, Brigitte Wdziekonski, Anne Baron, Pascal Fossat, Laurent Marsollier, Xavier Gasull, Eric Boué-Grabot, Michael A Kienzler, Guillaume Sandoz Abstract By endowing light control of neuronal activity, optogenetics and photopharmacology are

Identification of Lipid Biomarkers for Chronic Joint Pain Associated with Different Joint Diseases

Biomolecules 2023 Feb 9;13(2):342. doi: 10.3390/biom13020342. Spiro Khoury, Jenny Colas, Véronique Breuil, Eva Kosek, Aisha S Ahmed, Camilla I Svensson, Fabien Marchand, Emmanuel Deval, Thierry Ferreira Abstract Lipids, especially lysophosphatidylcholine LPC16:0, have been shown to be involved in chronic joint pain through the activation of acid-sensing ion

Guidelines of the International Headache Society for Controlled Clinical Trials in Cluster Headache

Cephalalgia 2022 Dec;42(14):1450-1466 doi: 10.1177/03331024221120266. Epub 2022 Oct 21. Jean Schoenen, Agneta Henriette Snoer, Roemer B Brandt, Rolf Fronczek, Diana Y Wei, Chin-Sang Chung, Hans-Christoph Diener, David W Dodick, Denys Fontaine, Peter J Goadsby, Manjit Singh Matharu, Arne May, James S McGinley, Stewart J Tepper, Rigmor Højland Jensen, Michel D Ferrari; IHS Standing Committee for Clinical

Mechanisms of Action of the Peptide Toxins Targeting Human and Rodent Acid-Sensing Ion Channels and Relevance to Their In Vivo Analgesic Effects

Toxins 2022 Oct 17;14(10):709.doi: 10.3390/toxins14100709. Clément Verkest, Miguel Salinas, Sylvie Diochot, Emmanuel Deval, Eric Lingueglia, Anne Baron Abstract Acid-sensing ion channels (ASICs) are voltage-independent H+-gated cation channels largely expressed in the nervous system of rodents and humans. At least six isoforms (ASIC1a, 1b, 2a, 2b,

Combining Awake Anesthesia with Minimal Invasive Surgery Optimizes Intraoperative Surgical Spinal Cord Stimulation Lead Placement

Journal of clinical medicine . 2022 Sep 22;11(19):5575. doi: 10.3390/jcm11195575. Philippe Rigoard, Amine Ounajim, Lisa Goudman, Chantal Wood, Manuel Roulaud, Philippe Page, Bertille Lorgeoux, Sandrine Baron, Kevin Nivole, Mathilde Many, Emmanuel Cuny, Jimmy Voirin, Denys Fontaine, Sylvie Raoul, Patrick Mertens, Philippe Peruzzi, François Caire, Nadia Buisset, Romain David, Maarten Moens, Maxime Billot Abstract Spinal cord stimulation (SCS) is an effective