PLoS Computational Biology 2025 Jun 4;21(6):e1013099. doi: 10.1371/journal.pcbi.1013099. eCollection 2025 Jun. Emre Baspinar, Martina Simonti , Hadi Srour, Mathieu Desroches , Daniele Avitabile , Massimo Mantegazza Abstract Cortical spreading depolarization (CSD) is a wave of depolarization with local onset and extended propagation implicated in several