Coordinator : Dr Michel Lantéri-Minet

Work package 1 called "Care, Evaluation & Database”,  is organized around 4 tasks in order to develop a comprehensive multidimensional refractory chronic pain assessment, to select best therapeutic options, and to build a shared database to follow-up this carefully studied cohort of rCP patients.

Task 1: Organization of healthcare network within the FHU

The two Pain Departments involved in INOV-PAIN are the two tertiary “pain centers” of the region PACA. As stated by the national guidelines of pain clinic organization (HAS), the missions of these departments are :

  • assessment of chronic pain patients using validated scales, scores or tools related to the biopsychosocial model of chronic pain (psychosocial context, previous treatments, coping factors) and using neurophysiological assessment to precise the underlying mechanisms of rCP
  • evaluation of impact of the individual disease burden
  • elaboration of a tailored care project.

Although these aspects are already performed quite similarly within the pain teams involved in INOVPAIN they are further harmonized through different programs.


Task 2: Refractory chronic pain patients cohort and database constitution

The adoption of common assessment protocol favors the constitution of a common follow-up cohort of patient and database, concerning patients suffering from: chronic daily headache, neuropathic pain, low back +/- radicular pain, and fibromyalgia, these pathologies accounting for more than 60% of the recruitment and corresponding to the expertise domains of our centers. Data included in this “RCP database” is collected prospectively, in real time, using dedicated software designed by Serviligne through connected tools (smartphones & tablets) (see WP5).

Task 3: Psycho-Social evaluation

Team R8, Axe Santé “Bien naître, bien vieillir” (Laboratoire d’Anthropologie et de Psychologie Cognitives et Sociales) selects, adapts and/or develops several scales exploring multiple psychological, emotional, behavioral, and social aspects of rCP patients. These data are included in the database.

Task 4: Tissue collection

In parallel and complement to database, we prospectively collect blood samples of patients included in the database in order to constitute a tissue collection, that is used to identify biomarkers of chronicity, treatment response and resistance.