Dr Eric Lingueglia

Institut de Pharmacologie Moléculaire et Cellulaire

660 Route des Lucioles
SOPHIA ANTIPOLIS
06560 VALBONNE

Team Ion channel and pain

Chronic pain is a major health problem that substantially reduces quality of life, affecting about 20% of adults and up to 50% of the elders. However, currently approved analgesics are often associated with poor tolerability, low compliance due to side effects, and concerns over long-term safety and abuse potential. Most pain therapeutics approved in the last decade are just new formulations of existing drugs, in part because of poor understanding of the underlying pathophysiology. In this context, the discovery of new drug targets represents a real opportunity for developing new strategies against pain.

ipmcpic

Acid-Sensing Ion Channels (ASICs), which form excitatory (depolarizing) cation channels activated by extracellular protons, and two pore domain background K+ channels (K2Ps), which form inhibitory (hyperpolarizing) potassium channels, are novel molecular targets for pain identified in recent years.

- Properties and regulation of ASIC channels - pathophysiological implications in pain (coordinator: E Deval).
- Pharmacology and structure/function relationships of ASIC channels (coordinator: E Lingueglia).
- Pathophysiology of K2P channels in pain (coordinator: J Noël).


Work Packages

Discover the main work modules of Inovpain FHU.


Research Teams

Several academic research teams participate in the INOVPAIN project.


Want to know more about pain ?

Find informations by visiting these websites.

Recent works


News

Latetest scientific articles about chronic pain.